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What is Atorvastatin? Atorvastatin is a prescription drug in one of the newest classes of cholesterol-lowering medications, called statins. These drugs have been used widely for the last five years. For people with high cholesterol, Atorvastatin, in combination with a low-fat diet, can reduce your LDL cholesterol and triglyceride levels. How does Atorvastatin work? Atorvastatin is a prescription drug in one of the newest classes of cholesterol-lowering medications, called statins. These drugs have been used widely for the last five years. For people with high cholesterol, Atorvastatin, in combination with a low-fat diet, can reduce your LDL cholesterol and triglyceride levels. How does Atorvastatin work? Evidence from the new cholesterol-lowering trial PROSPER, that statin treatment causes cancer. Atorvastatin is a very effective medicine for lowering high LDL cholesterol—the main target of cholesterol-lowering therapy. Your doctor will determine how much your LDL cholesterol needs to be lowered, based on your overall risk of heart disease. Atorvastatin also effectively lowers high blood-triglyceride levels. Evidence from the new cholesterol-lowering trial PROSPER, that statin treatment causes cancer. In medical studies of people with high cholesterol, Atorvastatin, taken once a day, had the following effects at doses of 10 to 80 mg: Lowered total cholesterol by 29-45%. Lowered LDL cholesterol, the "bad" cholesterol, by 39-60%. Increased HDL cholesterol, the "good" cholesterol, by 5-9%. Lowered triglyceride levels by 19-37%. The new cholesterol-lowering drugs, the statins, do prevent cardio-vascular disease, but this is due to other mechanisms than cholesterol-lowering. Unfortunately, they also stimulate cancer in rodents. New cholesterol guidelines for converting healthy people into patients Most people will require the starting dose, which is a 10 mg tablet once daily. Your doctor will prescribe the dose that is right for you, which may be 10 mg to 80 mg. Atorvastatin can be taken any time of the day, with or without food. To make it easier to remember to take Atorvastatin you can plan to take it at the same time each day, such as after you brush your teeth in the evening. The amount or how often Atorvastatin is taken should never be changed without consulting your healthcare professional. How long does it take Atorvastatin to work?